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Modular Next-Generation Drug Delivery Technology
DegradaBALL® is the original technology of Lemonex that enables the effective delivery of various new drug candidates into the
cultured cells or lesions by loading the drugs inside. It is a next-generation drug delivery technology optimized especially for the development
of gene therapy, cancer immunotherapy, antibody therapy, and synthetic drugs. Pre-existing drug delivery vectors such as liposomes,
micelles, and exosomes are inappropriate to maintain the size of the particles, the certain level of the concentration of the drug loaded,
and the stability of drug delivery system at room temperature. On the other hand, DegradaBALL® can control the size, the concentration,
and the stability uniformly with convenient procedure.
Advantages of DegradaBALL®
Highly Efficient and Rapid Neural Differentiation of Mouse Embryonic Stem Cells Based on Retinoic Acid Encapsulated Porous
Nanoparticle. Park SJ, Kim S, Kim SY, Jeon NL, Song JM, Won C, and Min DH. ACS Appl Mater Interfaces. 2017; 9(40): 34634-34640.
Development of Dual-Pore Coexisting Branched Silica Nanoparticles for Efficient Gene-Chemo Cancer Therapy.
Lee JH, Kang S, Ahn M, Jang H, and Min DH. Small. 2018; 14(7) Epub.
Direct cellular delivery of human proteasomes to delay tau aggregation. Han DH, Na HK, Choi WH, Lee JH, Kim YK, Won C,
Lee SH, Kim KP, Kuret J, Lee MJ, and Min DH. Nat Commun. 2014; 5(5): 5633
Efficient functional delivery of siRNA using mesoporous silica nanoparticles with ultralarge pores. Na HK, Kim MH, Park K,
Ryoo SR, Lee KE, Jeon H, Ryoo R, Hyeon C, and Min DH. Small. 2012; 8(11): 1752-61.
Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery.
Kim MH, Na HK, Kim YK, Ryoo SR, Cho HS, Lee KE, Jeon H, Ryoo R, and Min DH. ACS Nano. 2011; 5(5): 3568-76.